The influence of aspartic or glutamic acid residues in tetrapeptides on the formation of complexes with nickel(II) and zinc(II)
Identifieur interne : 000474 ( France/Analysis ); précédent : 000473; suivant : 000475The influence of aspartic or glutamic acid residues in tetrapeptides on the formation of complexes with nickel(II) and zinc(II)
Auteurs : H. Kozlowski [Pologne] ; A. Lebkiri [Maroc] ; Ch. O. Onindo [Royaume-Uni] ; L. D. Pettit [Royaume-Uni] ; J.-F. Galey [France]Source :
- Polyhedron [ 0277-5387 ] ; 1995.
Abstract
The formation of the complexes formed by NiII and ZnII with Asp-Asp-Asp and a series of tetrapeptides containing one or two Asp residues or one Glu residue are reported. Stability constants were measured pH-metrically. The particular species and the metal ion binding sites were determined using 1H NMR, UV-vis and CD spectroscopy. The β-carboxylate group of the Asp residue stabilizes the complexes significantly, particularly when present as the N-terminal residue. As a result the tendency for NiII to deprotonate and bind to amide-nitrogen atoms, forming planar diamagnetic complexes, is reduced and their formation delayed to a significantly higher pH when compared to other peptides. The side chain of the Glu residue has a much smaller effect. As anticipated, ZnII was unable to deprotonate and bind to peptide nitrogens.
Url:
DOI: 10.1016/0277-5387(94)00239-B
Affiliations:
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Stability constants were measured pH-metrically. The particular species and the metal ion binding sites were determined using 1H NMR, UV-vis and CD spectroscopy. The β-carboxylate group of the Asp residue stabilizes the complexes significantly, particularly when present as the N-terminal residue. As a result the tendency for NiII to deprotonate and bind to amide-nitrogen atoms, forming planar diamagnetic complexes, is reduced and their formation delayed to a significantly higher pH when compared to other peptides. The side chain of the Glu residue has a much smaller effect. As anticipated, ZnII was unable to deprotonate and bind to peptide nitrogens.</div></front></TEI><affiliations><list><country><li>France</li><li>Maroc</li><li>Pologne</li><li>Royaume-Uni</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Villeneuve d'Ascq</li></settlement></list><tree><country name="Pologne"><noRegion><name sortKey="Kozlowski, H" sort="Kozlowski, H" uniqKey="Kozlowski H" first="H." last="Kozlowski">H. Kozlowski</name></noRegion></country><country name="Maroc"><noRegion><name sortKey="Lebkiri, A" sort="Lebkiri, A" uniqKey="Lebkiri A" first="A." last="Lebkiri">A. Lebkiri</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Onindo, Ch O" sort="Onindo, Ch O" uniqKey="Onindo C" first="Ch. O." last="Onindo">Ch. O. Onindo</name></noRegion><name sortKey="Pettit, L D" sort="Pettit, L D" uniqKey="Pettit L" first="L. D." last="Pettit">L. D. Pettit</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Galey, J F" sort="Galey, J F" uniqKey="Galey J" first="J.-F." last="Galey">J.-F. Galey</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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